Since version7.0 of SmartPOP2Exchange it saves its settings in an XML files in the "%COMMONAPPDATA%" folder:
C:\Documents and Settings\All Users\Application Data\JAM Software\SmartPOP2Exchange\SmartPOP2ExchangeSettings.xml
You can easily include your SmartPOP2Exchange (the XML file) settings in your backup by adding this file.
Yes, they will. It doesn't matter if you upgrade to a newer version, to a bigger version (from 10 POP3/IMAP accounts to unlimited) or if you previously had the trial version, your settings will be used by the new installation.
SmartPOP2Exchange works with any SMTP server. Since it uses the SMTP protocol to send/deliver the mail to the server, it just has to be able to communicate to port 25 (changeable) of the SMTP server.
General settings for each virus scanner that you want to use with "Exchange Server Toolbox" or "SmartPOP2Exchange" are - If a virus is found (files and archives), no user interaction (asking) may be required. Select "Delete file" or "Rename/Move file". - Disable any scanning of POP3/IMAP and SMTP protocols. This option is usually described as "Scan inbound/outbound email".
You can also use the integrated ClamAV virus scanner in addition to your own.